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![Peg Peg](/uploads/1/3/3/9/133905695/979255507.jpg)
![Peg Dmg Peg Dmg](/uploads/1/3/3/9/133905695/599523433.png)
Lipid Nanoparticle Delivery
Recently developed lipid nanoparticle (LNP) formulations of siRNA have proven to be effective agents for hepatocyte gene silencing following intravenous administration with at least three LNP-siRNA formulations in clinical trials. The aim of this work was to develop LNP-siRNA systems for hepatocyte gene silencing that can be administered subcutaneously (s.c.). Three parameters were investigated, namely LNP size, residence time of the polyethylene glycol (PEG)-lipid coating and the influence of hepatocyte-specific targeting ligands. LNP sizes were varied over the range of 30 to 115 nm in diameter and PEG-lipid that dissociates rapidly (PEG-DMG) and slowly (PEG-DSG) were employed. In mice, results show that large (~80 nm) LNP exhibited limited accumulation in the liver and poor Factor VII (FVII) gene silencing at 1mg siRNA/kg body weight. Conversely, small (~30 nm) LNP systems showed maximal liver accumulation yet still had minimal activity. Interestingly, intermediate size (~45 nm) LNP containing PEG-DSG exhibited nearly equivalent liver accumulation as the smaller systems following s.c. administration but reduced FVII levels by 80% at 1mg siRNA/kg body weight. Smaller systems (~35 nm diameter) containing either PEG-DMG or PEG-DSG were less active; however addition of 0.5 mol.% of a GalNAc-PEG lipid to these smaller systems improved activity to levels similar to that observed for the ~45 nm diameter systems. In summary, this work shows that appropriately designed LNP-siRNA systems can result in effective hepatocyte gene silencing following s.c administration.
DMG-PEG 2000 is suitable for use in the preparation of lipid nanoparticle for microRNA and short interfering RNA delivery. Biochem/physiol Actions Dimyristoyl glycerol (DMG) − polyethyleneglycol (PEG) 2000 is used for liposome preparation for anticancer drug delivery studies for hepatocellular, gastrointestinal, neuroendocrine. We are here to help. Reach out for Help and Support or Sales.
Peg Derivatives
Dmg Mori Co PEG Ratio is 0.38 as of today(2019-10-25). Dmg Mori Co PEG Ratio explanation, calculation, historical data and more. SUNBRIGHT® GM-020(DMG-PEG) $ 176.00. Package size: 1g amber glass bottle 10g aluminum pouch (+ $ 1,414.00) CODE: Availability: In stock. The following version: 1.1 is the most frequently downloaded one by the program users. The program belongs to Games. This application's bundle is identified as com.mps.pegsolitaire. Our built-in antivirus checked this Mac download and rated it as virus free. The common filename for the program's installer is Peg-solitaire1.1.dmg.